
Procarbazine hydrochloride
CAS No. 366-70-1
Procarbazine hydrochloride( Indicarb | Matulane | Natulan | NSC 77213 )
Catalog No. M14259 CAS No. 366-70-1
Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
Purity : >98% (HPLC)






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Biological Information
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Product NameProcarbazine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionProcarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
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DescriptionProcarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. Procarbazine interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis. Procarbazine hydrochloride (Matulane) is used in the treatment of Hodgkin’s lymphoma and other malignant lymphomas including:- lymphosarcoma- reticulosarcoma- Brill-Symmers disease. Because procarbazine hydrochloride (Matulane) works differently to other anticancer agents,Procarbazine hydrochloride (Matulane) may be useful in the treatment of Ys that have not responded to other treatments.
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In VitroCell Viability Assay Cell Line:L1210 cells Concentration:5 and 20 nM Incubation Time:1 hour Result:Showed 99.3% and 99.9% survival of cells at 5 mM and 20 mM, respectively.
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In VivoAnimal Model:Male muta mouse (7–8 weeks old)Dosage:50 and 150 mg/kg Administration:Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 days Result:Increased the MN frequency appreciably, and observed micronucleus induction in the peripheral blood at 50 mg/kg.
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SynonymsIndicarb | Matulane | Natulan | NSC 77213
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number366-70-1
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Formula Weight257.76
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Molecular FormulaC12H19N3O·HCl
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Purity>98% (HPLC)
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SolubilityEthanol: 52 mg/mL (201.73 mM); Water: 52 mg/mL (201.73 mM)
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SMILESCl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ogawa K, et al. Mutat Res. 2003 Aug 5;539(1-2):145-55.
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