Procarbazine hydrochloride

Research use only, not for human use.

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. Procarbazine interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis. Procarbazine hydrochloride (Matulane) is used in the treatment of Hodgkin’s lymphoma and other malignant lymphomas including:- lymphosarcoma- reticulosarcoma- Brill-Symmers disease. Because procarbazine hydrochloride (Matulane) works differently to other anticancer agents,Procarbazine hydrochloride (Matulane) may be useful in the treatment of Ys that have not responded to other treatments.

Cell Viability Assay Cell Line:L1210 cells Concentration:5 and 20 nM Incubation Time:1 hour Result:Showed 99.3% and 99.9% survival of cells at 5 mM and 20 mM, respectively.

Animal Model:Male muta mouse (7–8 weeks old)Dosage:50 and 150 mg/kg Administration:Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 days Result:Increased the MN frequency appreciably, and observed micronucleus induction in the peripheral blood at 50 mg/kg.

Indicarb | Matulane | Natulan | NSC 77213

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA/RNA Synthesis

Cancer

——

366-70-1

257.76

C12H19N3O·HCl

>98% (HPLC)

Ethanol: 52 mg/mL (201.73 mM); Water: 52 mg/mL (201.73 mM)

Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C

——

(-20℃)

With Ice Pack

≥ 2 years